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Tuesday, February 15th, 2005
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Rat brain's executive hub quells alarm center if stress is controllable
When it deems a stressor controllable, an executive hub in the front of the brain quells an alarm center deep in the brainstem, preventing the adverse behavioral and physiological effects of uncontrollable stress. Rats exposed to uncontrollable stress develop learned helplessness, a syndrome similar to depression. "It's as if the prefrontal cortex says: 'Cool it, brainstem! We have control over this and there is no need to get so excited'," quipped Steven Maier, Ph.D.
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