Y-chromosome STR haplotype diversity in Brazilian populations

[Euclides]

Forensic Sci Int. 2005 Apr 20;149(1):99-107.

Y-chromosome STR haplotype diversity in Brazilian populations.

Grattapaglia D, Kalupniek S, Guimaraes CS, Ribeiro MA, Diener PS, Soares CN.

Hereditas Tecnologia em Analise de DNA Ltda., SHIN CA 02, Lote 19, Brasilia, DF 71505-000, Brazil.

A sample of 198 unrelated males distributed among the five geopolitical regions in Brazil were typed for the minimal Y-STR haplotype composed of microsatellite loci DYS19, DYS385I/II, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393. Gene frequency data, gene diversity, haplotype diversity and power of discrimination were estimated. An AMOVA indicated that 99.97% of the haplotypic variation is found within regions and only a small 0.03% and non significant variation is found among the five regions (Fst=0.00031, P-value=0.43). This result suggests that a single national database of Y-STR haplotypes can be used in the quantitative assessment of matches in forensic casework in the Brazilian population. A significant haplotype diversity of 99.8% was found and 172 different haplotypes were observed in 198 chromosomes. Haplotype (14-11, 14-13-29-24-11-13-13) with five occurrences in 198 chromosomes was the most frequent in Brazil.